Mayuko Sasaki
- Birthday: September 06, 1970, 56 years old
- Place of Birth: Hiroshima, Japan
- Known For: Acting
- Biography: Mayuko Sasaki is a Japanese actress and striptease dancer. She was named Best Actress at the 2010 Pink Taishō for her performance in director Yutaka Ikejima's Yokubō no sakaba: Nure niō iro onna.